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pyaging/systemsagemetabolic

sourceHugging Faceupdated 8d agoView on Hugging Face

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Model Card

systemsagemetabolic

Metabolic-system component of Systems Age: a whole-blood DNAm score built from metabolic-system biomarkers and mortality training, returned on an age-like scale.

Model weights retain the original authors' terms; the pyaging software license does not relicense them. These weights are restricted to research use under the authors' terms.


Predicts	metabolic-system biological age
Species	Homo sapiens
Tissue	whole blood
Data type	DNA methylation
Model type	PCA + elastic net regression
Year	2025

Use with pyaging

python

import pyaging as pya

pya.pred.predict_age(adata, ["systemsagemetabolic"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Sehgal, R., Markov, Y., Qin, C., et al. (2025). Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems. Nature Aging, 5, 1880–1896.

https://doi.org/10.1038/s43587-025-00958-3