Modelpublic

recursionpharma/nesso

sourceHugging Faceapache-2.0updated 2mo agoView on Hugging Face

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Model Card

Model Card for Nesso-1

Nesso-1 is a fast, structure-based protein–ligand binding-affinity model. Given a protein sequence and a ligand (SMILES / CCD code / SDF), it predicts a binding affinity scalar along with a binder/non-binder score.

—Developed by: Valence Labs (Recursion)
—Input modality: Protein Amino-Acid sequence + Ligand (SMILES, CCD code, or SDF)
—License: Apache License 2.0
—Paper: Technical Report

For full method details and evaluations, see the Technical Report and Github

Documentation

Install the package, run predictions, and explore examples from the GitHub repository:

—README — installation, quick start, and development setup
—docs/prediction.md — CLI options, input YAML schema, and output format
—tutorial/ — runnable YAML examples and feature extraction
—Issues - For questions related to weights, model code, please raise issues here.